Lentigo maligna and lentigo maligna melanoma in patients younger than 50â
years: a multicentre international clinical-dermoscopic study.
Clin Exp Dermatol
; 49(2): 128-134, 2024 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-37758301
ABSTRACT
BACKGROUND:
Lentigo maligna/lentigo maligna melanoma (LM/LMM) is usually diagnosed in older patients, when lesions are larger. However, it is important to detect it at an earlier stage to minimize the area for surgical procedure.OBJECTIVES:
To determine and define clinical, dermoscopic and reflectance confocal microscopy (RCM) features of LM/LMM in patients < 50â years old.METHODS:
This was a multicentre study involving tertiary referral centres for skin cancer management. The study included cases of consecutively excised LM/LMM arising in patients < 50â years of age with a histopathological diagnosis of LM/LMM and a complete set of clinical and dermoscopic images; RCM images were considered when present.RESULTS:
In total, 85 LM/LMM of the face from 85 patients < 50â years were included in the study. A regression model showed a direct association with the size of the lesion (R2 = 0.08; P = 0.01) and with the number of dermoscopic features at diagnosis (R2 = 0.12; P < 0.01). In a multivariable analysis, an increasing number of dermoscopic features correlated with increased patient age (P < 0.01), while the presence of grey colour was a predictor of younger age at diagnosis (P = 0.03). RCM revealed the presence of melanoma diagnostic features in all cases (pagetoid cells and atypical nesting).CONCLUSIONS:
LM is not a disease limited to older people as previously thought. LM presenting in young adults tends to be smaller and with fewer dermoscopic features, making its diagnosis challenging. Careful evaluation of facial pigmented lesions prior to cosmetic procedures is imperative to avoid incorrectly treating early LM as a benign lesion.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Sarda Melanótica de Hutchinson
/
Melanoma
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article