Nuclear NPM-ALK Protects Myc from Proteasomal Degradation and Contributes to Its High Expression in Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma.

Shang, Chuquan; Lai, Justine; Haque, Moinul; Chen, Will; Wang, Peng; Lai, Raymond

Shang, Chuquan; Lai, Justine; Haque, Moinul; Chen, Will; Wang, Peng; Lai, Raymond.

Afiliação

Shang C; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Lai J; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Haque M; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Chen W; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA.
Wang P; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Lai R; Department of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Int J Mol Sci ; 24(18)2023 Sep 20.

Article em En | MEDLINE | ID: mdl-37762644

Assuntos

Linfoma Anaplásico de Células Grandes; Humanos; Linfoma Anaplásico de Células Grandes/genética; Quinase do Linfoma Anaplásico/genética; Células HEK293; Meia-Vida; Imunoprecipitação

Palavras-chave

ALK-positive anaplastic lymphoma; Myc; cancer stemness; proteasomal degradation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes Idioma: En Ano de publicação: 2023 Tipo de documento: Article