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Bioassay-guided isolation, identification and activity evaluation of antifungal compounds from Cupressus sempervirens.
Safa, Rguez; Walid, Yeddes; Affes, Taycir Grati; Hammami, Majdi; Sellami, Ibtissem Hamrouni.
Afiliação
  • Safa R; Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria, Hammam-Lif, BP, Tunisia.
  • Walid Y; Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria, Hammam-Lif, BP, Tunisia.
  • Affes TG; Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria, Hammam-Lif, BP, Tunisia.
  • Hammami M; Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria, Hammam-Lif, BP, Tunisia.
  • Sellami IH; Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria, Hammam-Lif, BP, Tunisia.
Int J Environ Health Res ; : 1-12, 2023 Sep 28.
Article em En | MEDLINE | ID: mdl-37767807
The quest for eco-friendly antifungal compounds from natural sources has surged, seeking alternatives to synthetic fungicides. In this study, we explored Cupressus sempervirens organic extracts antifungal potential against Botrytis cinerea, a destructive fungus causing grey mold disease in crops. Extracts from various phenological stages were evaluated for their antifungal activities. The dichloromethanolic extract from the flowering stage exhibited the highest efficacy, completely inhibiting B. cinerea mycelial growth, at 250 µg/mL and preventing conidia germination at 500 µg/mL. Bioguided fractionation and chromatography, led to the identification of isoquercetin as the active compound responsible for the antifungal effects. These findings present promising possibilities for the development of sustainable biofungicides to combat grey mould disease in agriculture. Further investigations into isoquercetin's potential as a biofungicide are warranted.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article