UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.
Oncotarget
; 14: 843-857, 2023 09 28.
Article
em En
| MEDLINE
| ID: mdl-37769033
ABSTRACT
UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.
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Base de dados:
MEDLINE
Assunto principal:
Uridina Difosfato Glucose Desidrogenase
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Neoplasias
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article