Tug-of-war via ERK signaling pathway for tissue organization - ERK activation to force generation.
Curr Opin Cell Biol
; 85: 102249, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37783032
ABSTRACT
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell behaviors observed in diverse biological phenomena. Emerging studies have shed light on the involvement of the ERK signaling pathway in the reception and generation of mechanical forces, thereby governing local mechanical interactions within multicellular tissues. Although limited in number, studies have provided insights into how ERK-mediated mechanical interactions contribute to multicellular organization. Here we explore the impact of ERK-mediated mechanical interactions on tissue morphogenesis, cell extrusion in homeostasis, and their interplay with the physical microenvironments of the extracellular matrix. We conclude that the coupling system of ERK activity with mechanical forces offers a promising avenue to unravel the emergent collective dynamics underlying tissue organization.
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MEDLINE
Assunto principal:
Transdução de Sinais
/
MAP Quinases Reguladas por Sinal Extracelular
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article