Eight-Membered Palladacycle Intermediate Enabled Synthesis of Cyclic Biarylphosphonates.
Chemistry
; 30(3): e202302416, 2024 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-37792811
ABSTRACT
Transition-metal-catalyzed coupling reactions that involve the direct functionalization of insert C-H bond represent one of the most efficient strategies for forming carbon-carbon bonds. Herein, a palladium-catalyzed intramolecular C-H bond arylation of triaryl phosphates is reported to access seven-membered cyclic biarylphosphonate targets. The reaction is achieved via a unique eight-membered palladacyclic intermediate and shows good functional group compatibility. Meanwhile, the product can be readily converted into other valuable phosphate compounds.
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MEDLINE
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En
Ano de publicação:
2024
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Article