Protein Z and Protein Z-dependent protease inhibitor in patients with acute ischemic stroke: A prospective mechanistic study.
J Stroke Cerebrovasc Dis
; 32(12): 107403, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37804782
ABSTRACT
OBJECTIVES:
Protein Z (PZ) /Protein Z-dependent protease inhibitor (ZPI) (PZ/ZPI) system is a new anticoagulant system discovered in recent years, which plays an important role in many diseases. We aimed to compare the plasma PZ/ZPI levels of acute ischemic stroke (AIS) patients and non-stroke control participants and the role of PZ/ZPI in the development of stroke was preliminarily analyzed. MATERIALS ANDMETHODS:
Enzyme linked immunosorbent assay (ELISA) was used to detect and compare plasma PZ levels of 86 patients with acute AIS and 85 non-stroke control patients. Multivariable Logistic regression was used to analyze whether PZ was an independent risk factor for AIS.RESULTS:
In the present study, plasma PZ is closely related to inflammatory response, coagulation process and platelet activation, and may participate in the development of AIS by inducing inflammatory responses and interfering with the coagulation process.CONCLUSIONS:
Our results suggested that plasma PZ level is one of the independent risk factors of AIS, and plasma ZPI was closely related to coagulation and platelet parameter and may play a role in the coagulation process during AIS.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Serpinas
/
AVC Isquêmico
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article