PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway.

Zhao, Linjun; Hu, Jiahui; Zheng, Pingping; Mi, Ben; Chen, Zixi; Zhao, Xu; Wu, Jinhong; Wang, Yi

Zhao, Linjun; Hu, Jiahui; Zheng, Pingping; Mi, Ben; Chen, Zixi; Zhao, Xu; Wu, Jinhong; Wang, Yi.

Afiliação

Zhao L; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China.
Hu J; Department of Pathology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Rd, Hangzhou City 310052, China.
Zheng P; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China.
Mi B; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China.
Chen Z; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China.
Zhao X; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China.
Wu J; Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medical, 261 Huansha Rd, Hangzhou City 310006, China. Electronic address: wujinhong568@163.com.
Wang Y; Department of Emergency, Hangzhou Tranditional Chinese Medicine Hospitial Affiliated to Zhejiang Chinese Medical University, 453 Stadium Rd, Hangzhou City 310007, China. Electronic address: 1873098337@qq.com.

Int Immunopharmacol ; 124(Pt B): 110992, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37806106

Assuntos

Receptor PAR-1; Sepse; Humanos; Camundongos; Animais; Receptor PAR-1/metabolismo; Actinas/metabolismo; Fosforilação; Lipopolissacarídeos/farmacologia; Transdução de Sinais; Células Endoteliais da Veia Umbilical Humana/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Sepse/metabolismo; Quinases Associadas a rho/metabolismo; Permeabilidade Capilar

Palavras-chave

Endothelial barrier dysfunction; F-actin; Protease-activated receptor 1; RhoA/ROCK; phosphorylation of ERM

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Receptor PAR-1 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Receptor PAR-1 Idioma: En Ano de publicação: 2023 Tipo de documento: Article