Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes.

Schroeder, Philip; Mandla, Ravi; Huerta-Chagoya, Alicia; Alkanak, Ahmed; Nagy, Dorka; Szczerbinski, Lukasz; Madsen, Jesper G S; Cole, Joanne B; Porneala, Bianca; Westerman, Kenneth; Li, Josephine H; Pollin, Toni I; Florez, Jose C; Gloyn, Anna L; Cebola, Inês; Manning, Alisa; Leong, Aaron; Udler, Miriam; Mercader, Josep M

Schroeder, Philip; Mandla, Ravi; Huerta-Chagoya, Alicia; Alkanak, Ahmed; Nagy, Dorka; Szczerbinski, Lukasz; Madsen, Jesper G S; Cole, Joanne B; Porneala, Bianca; Westerman, Kenneth; Li, Josephine H; Pollin, Toni I; Florez, Jose C; Gloyn, Anna L; Cebola, Inês; Manning, Alisa; Leong, Aaron; Udler, Miriam; Mercader, Josep M.

Afiliação

Schroeder P; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Mandla R; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Huerta-Chagoya A; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Alkanak A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Nagy D; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Szczerbinski L; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Madsen JGS; Department of Medicine and Cardiovascular Research Institute, Cardiology Division, University of California, San Francisco, CA, USA.
Cole JB; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Porneala B; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Westerman K; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Li JH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pollin TI; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Florez JC; National Heart and Lung Institute, Faculty of Medicine, London, UK.
Gloyn AL; Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, 15-276, Poland.
Cebola I; Clinical Research Centre, Medical University of Bialystok, Bialystok, 15-276, Poland.
Manning A; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Leong A; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Udler M; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Mercader JM; Institute of Mathematics and Computer Science, University of Southern Denmark, Odense M, 5230, Denmark.

medRxiv ; 2023 Sep 29.

Article em En | MEDLINE | ID: mdl-37808701

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article