Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.

Ke, Wencan; Wang, Bingjin; Liao, Zhiwei; Song, Yu; Li, Gaocai; Ma, Liang; Wang, Kun; Li, Shuai; Hua, Wenbin; Yang, Cao

Ke, Wencan; Wang, Bingjin; Liao, Zhiwei; Song, Yu; Li, Gaocai; Ma, Liang; Wang, Kun; Li, Shuai; Hua, Wenbin; Yang, Cao.

Afiliação

Ke W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Ma L; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hua W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. huawb1987@163.com.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yangcao1971@sina.com.

J Transl Med ; 21(1): 711, 2023 10 10.

Article em En | MEDLINE | ID: mdl-37817199

Assuntos

Degeneração do Disco Intervertebral; Disco Intervertebral; Humanos; Degeneração do Disco Intervertebral/patologia; Dinâmica Mitocondrial; Mecanotransdução Celular; Espécies Reativas de Oxigênio/metabolismo; Apoptose; Dinaminas/metabolismo; Dinaminas/farmacologia; Disco Intervertebral/patologia

Palavras-chave

Intervertebral disc degeneration; Matrix stiffness; Mechanotransduction; Mitochondrial fission; Nucleus pulposus; Piezo1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração do Disco Intervertebral / Disco Intervertebral Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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