Lower serum Klotho level and higher systemic immune-inflammation index: an inverse correlation.
BMC Geriatr
; 23(1): 650, 2023 10 11.
Article
em En
| MEDLINE
| ID: mdl-37821820
ABSTRACT
OBJECTIVES:
Klotho, an anti-aging protein, has been identified to control tissue inflammatory responses. The objective of this research is to determine the linkage between soluble Klotho (S-Klotho) level and systemic immune-inflammation index (SII).METHODS:
Eligible participants with complete information of S-Klotho level and SII were selected from the National Health and Nutrition Examination Surveys (NHANES). Subsequently, weighted multivariate linear regression and subgroup analysis were carried out to evaluate the association.RESULTS:
Totally, 11,108 adults with complete data on S-Klotho level, SII and other important covariates were included in final analysis. Multivariate liner regression revealed that high level of S-Klotho was associated with low level of SII after multivariate adjustments (ß=-0.08, 95%CI-0.10- -0.05, P < 0.01). When classifying S-Klotho into tertiles, participants in S-Klotho tertile 3 (Q3) showed a decrease in SII level compared with those in the lowest tertile (Q1) (ß=-45.44, 95%CI-64.41- -26.47, P < 0.01 ). The negative associations remained significant regardless of age and gender, and varied depending on smoking status and BMI subgroups.CONCLUSION:
S-Klotho level was negatively related to SII after controlling for covariates. Further studies need to validate current findings and explore the fundamental mechanisms.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Inflamação
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article