Microbisporicin (NAI-107) protects Galleria mellonella from infection with Neisseria gonorrhoeae.
Microbiol Spectr
; 11(6): e0282523, 2023 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-37823634
ABSTRACT
IMPORTANCE We screened 66 bacteriocins to see if they exhibited anti-gonococcal activity. We found 12 bacteriocins with anti-gonococcal effects, and 4 bacteriocins showed higher anti-gonococcal activity. Three bacteriocins, lacticin Z, lacticin Q, and Garvicin KS (ABC), showed in vitro anti-gonococcal activity but no in vivo inhibitory effects against the Neisseria gonorrhoeae (WHO-P) isolate. On the other hand, NAI-107 showed in vivo anti-gonococcal activity. The findings suggest that NAI-107 is a promising alternative to treat gonorrhea infections.
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Base de dados:
MEDLINE
Assunto principal:
Bacteriocinas
/
Gonorreia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article