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Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.
Lau, Mei Sheng; Hu, Zhenhua; Zhao, Xiaodan; Tan, Yaw Sing; Liu, Jinyue; Huang, Hua; Yeo, Clarisse Jingyi; Leong, Hwei Fen; Grinchuk, Oleg V; Chan, Justin Kaixuan; Yan, Jie; Tee, Wee-Wei.
Afiliação
  • Lau MS; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore. mslau@imcb.a-star.edu.sg.
  • Hu Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Republic of Singapore.
  • Zhao X; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, China.
  • Tan YS; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, China.
  • Liu J; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou, China.
  • Huang H; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Yeo CJ; Department of Physics, National University of Singapore, Singapore, 117551, Singapore.
  • Leong HF; Centre for Bioimaging Sciences, National University of Singapore, Singapore, 117557, Singapore.
  • Grinchuk OV; Bioinformatics Institute (BII), A*STAR, 30 Biopolis Street, Matrix, Singapore, 138671, Singapore.
  • Chan JK; Genome Institute of Singapore (GIS), A*STAR, 60 Biopolis Street, Genome, Singapore, 138672, Singapore.
  • Yan J; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Tee WW; Electrophysiology Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nat Commun ; 14(1): 6464, 2023 10 13.
Article em En | MEDLINE | ID: mdl-37833256
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / DNA Topoisomerases Tipo I Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / DNA Topoisomerases Tipo I Idioma: En Ano de publicação: 2023 Tipo de documento: Article