Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.

Boden, Elisa K; Kongala, Ramya; Hindmarch, Duncan C; Shows, Donna M; Juarez, Julius G; Lord, James D

Boden, Elisa K; Kongala, Ramya; Hindmarch, Duncan C; Shows, Donna M; Juarez, Julius G; Lord, James D.

Afiliação

Boden EK; Center for Translational Research, Benaroya Research Institute, Seattle, WA, USA.
Kongala R; Division of Gastroenterology, Oregon Health and Science University, Portland, OR, USA.
Hindmarch DC; Center for Translational Research, Benaroya Research Institute, Seattle, WA, USA.
Shows DM; Center for Translational Research, Benaroya Research Institute, Seattle, WA, USA.
Juarez JG; Center for Translational Research, Benaroya Research Institute, Seattle, WA, USA.
Lord JD; GI Drug Discovery, Takeda Pharmaceuticals, Cambridge, MA, USA.

Inflamm Bowel Dis ; 2023 Oct 14.

Article em En | MEDLINE | ID: mdl-37837660

Vedolizumab had no effect on the number or gene expression of memory T lymphocytes in the colons of recipients relative to control individuals. However, the colons of vedolizumab-responsive patients had distinctly fewer dendritic cells, which in blood express the most integrin α4ß7.

Palavras-chave

T cell; dendritic cell; integrin; vedolizumab

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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