Multiscale simulation of the effect of low-intensity pulsed ultrasound on the mechanical properties distribution of osteocytes.
Comput Methods Biomech Biomed Engin
; : 1-13, 2023 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-37842824
ABSTRACT
Low-intensity pulsed ultrasound (LIPUS) is a potential effective means for the prevention and treatment of disuse osteoporosis. In this paper, the effect of LIPUS exposure on the mechanical properties distribution of the osteocyte system (osteocyte body contains nucleus, osteocyte process, and primary cilia) is simulated. The results demonstrate that the mechanical micro-environment of the osteocyte is significantly improved by ultrasound exposure, and the mean von Mises stress of the osteocyte system increases linearly with the excitation sound pressure amplitude. The mechanical effect of LIPUS on osteocytes is enhanced by the stress amplification mechanism of the primary cilia and osteocyte processes.
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MEDLINE
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En
Ano de publicação:
2023
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Article