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Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor.
Yano, Hideaki; Chitsazi, Rezvan; Lucaj, Christopher; Tran, Phuong; Hoffman, Alexander F; Baumann, Michael H; Lupica, Carl R; Shi, Lei.
Afiliação
  • Yano H; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States.
  • Chitsazi R; Computational Chemistry and Molecular Biophysics Section, National Institutes of Health, Baltimore, Maryland 21224, United States.
  • Lucaj C; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States.
  • Tran P; Computational Chemistry and Molecular Biophysics Section, National Institutes of Health, Baltimore, Maryland 21224, United States.
  • Hoffman AF; Electrophysiology Research Section, National Institutes of Health, Baltimore, Maryland 21224, United States.
  • Baumann MH; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States.
  • Lupica CR; Electrophysiology Research Section, National Institutes of Health, Baltimore, Maryland 21224, United States.
  • Shi L; Computational Chemistry and Molecular Biophysics Section, National Institutes of Health, Baltimore, Maryland 21224, United States.
ACS Chem Neurosci ; 14(21): 3928-3940, 2023 11 01.
Article em En | MEDLINE | ID: mdl-37847546
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabinoides / Agonistas de Receptores de Canabinoides Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canabinoides / Agonistas de Receptores de Canabinoides Idioma: En Ano de publicação: 2023 Tipo de documento: Article