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Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.
Ge, Yi-Jun; Wu, Bang-Sheng; Zhang, Yi; Chen, Shi-Dong; Zhang, Ya-Ru; Kang, Ju-Jiao; Deng, Yue-Ting; Ou, Ya-Nan; He, Xiao-Yu; Zhao, Yong-Li; Kuo, Kevin; Ma, Qing; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Artiges, Eric; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Lemaitre, Herve; Paus, Tomás; Poustka, Luise; Hohmann, Sarah; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Feng, Jian-Feng; Tan, Lan; Dong, Qiang; Schumann, Gunter; Cheng, Wei; Yu, Jin-Tai.
Afiliação
  • Ge YJ; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Wu BS; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhang Y; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Chen SD; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhang YR; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Kang JJ; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
  • Deng YT; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Ou YN; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
  • He XY; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhao YL; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
  • Kuo K; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
  • Ma Q; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Barker GJ; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Bokde ALW; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  • Desrivières S; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.
  • Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Grigis A; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
  • Garavan H; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Gowland P; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
  • Heinz A; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
  • Brühl R; Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
  • Martinot JL; Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.
  • Martinot MP; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.
  • Artiges E; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.
  • Nees F; AP-HP, Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
  • Orfanos DP; Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 'Trajectoires développementales & psychiatrie', University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.
  • Lemaitre H; Psychiatry Department, EPS Barthélémy Durand, Etampes, France.
  • Paus T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Poustka L; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Hohmann S; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
  • Millenet S; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Fröhner JH; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Smolka MN; Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, Bordeaux, France.
  • Vaidya N; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
  • Walter H; Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Whelan R; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
  • Feng JF; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Tan L; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Dong Q; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Schumann G; Centre for Population Neuroscience and Stratified Medicine, Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Cheng W; Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
  • Yu JT; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Nat Hum Behav ; 8(1): 164-180, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37857874
ABSTRACT
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits. Genome-wide association analysis in a discovery sample of 31,880 individuals identified 62 unique loci and 785 candidate genes associated with ventricular morphology. We replicated over 80% of loci in a well-matched cohort of lateral ventricular volume. Gene set analysis revealed enrichment of ventricular-trait-associated genes in biological processes and disease pathogenesis during both early brain development and degeneration. We explored the age-dependent genetic associations in cohorts of different age groups to investigate the possible roles of ventricular-trait-associated loci in neurodevelopmental and neurodegenerative processes. We describe the genetic overlap between ventricular and neuropsychiatric traits through comprehensive integrative approaches under correlative and causal assumptions. We propose the volume of the inferior lateral ventricles as a heritable endophenotype to predict the risk of Alzheimer's disease, which might be a consequence of prodromal Alzheimer's disease. Our study provides an advance in understanding the genetics of the cerebral ventricles and demonstrates the potential utility of ventricular measurements in tracking brain disorders and maintaining brain health across the lifespan.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2024 Tipo de documento: Article