Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis.

Li, Yuanlong; Fan, Hua; Han, Xiong; Sun, Jun; Ni, Ming; Hou, Xiaodan; Fang, Fengqin; Zhang, Wei; Ma, Peizhi

Li, Yuanlong; Fan, Hua; Han, Xiong; Sun, Jun; Ni, Ming; Hou, Xiaodan; Fang, Fengqin; Zhang, Wei; Ma, Peizhi.

Afiliação

Li Y; Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan, China.
Fan H; Department of Pharmacy, People's Hospital of Zhengzhou University, Zhengzhou University, No. 7 Weiwu Road, Zhengzhou, 450000, Henan, China.
Han X; Department of Pharmacy, People's Hospital of Henan University, School of Clinical Medicine, Henan University, Zhengzhou, 450000, Henan, China.
Sun J; School of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Henan University of Science and Technology, Luoyang, 471003, Henan, China.
Ni M; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan, China.
Hou X; Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan, China.
Fang F; Department of Pharmacy, People's Hospital of Zhengzhou University, Zhengzhou University, No. 7 Weiwu Road, Zhengzhou, 450000, Henan, China.
Zhang W; Department of Pharmacy, People's Hospital of Henan University, School of Clinical Medicine, Henan University, Zhengzhou, 450000, Henan, China.
Ma P; Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan, China.

Mol Neurobiol ; 61(4): 2136-2150, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37858031

Assuntos

MicroRNAs; RNA Longo não Codificante; Traumatismos da Medula Espinal; Ratos; Animais; MicroRNAs/genética; RNA Longo não Codificante/genética; Microglia/metabolismo; Doenças Neuroinflamatórias; Ratos Sprague-Dawley; Lipopolissacarídeos/farmacologia; Inflamação/metabolismo; Traumatismos da Medula Espinal/metabolismo; Apoptose; Medula Espinal/metabolismo

Palavras-chave

Microglia polarization; Neural apoptosis; Spinal cord injury; lncRNA MALAT1; miR-125b-5p

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / MicroRNAs / RNA Longo não Codificante Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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