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T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.
Denis, Colin; Dabbs, Kevin; Nair, Veena A; Mathis, Jedidiah; Almane, Dace N; Lakshmanan, Akshayaa; Nencka, Andrew; Birn, Rasmus M; Conant, Lisa; Humphries, Colin; Felton, Elizabeth; Raghavan, Manoj; DeYoe, Edgar A; Binder, Jeffrey R; Hermann, Bruce; Prabhakaran, Vivek; Bendlin, Barbara B; Meyerand, Mary E; Boly, Mélanie; Struck, Aaron F.
Afiliação
  • Denis C; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Dabbs K; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Nair VA; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Mathis J; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Almane DN; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Lakshmanan A; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Nencka A; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Birn RM; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Conant L; Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Humphries C; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Felton E; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Raghavan M; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • DeYoe EA; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Binder JR; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Hermann B; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Prabhakaran V; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Bendlin BB; Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Meyerand ME; Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Boly M; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Struck AF; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ann Clin Transl Neurol ; 10(11): 2149-2154, 2023 11.
Article em En | MEDLINE | ID: mdl-37872734
ABSTRACT
Short-range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age-matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group-level aberrations in overall myelin content or myelin changes through time in TLE.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epilepsia do Lobo Temporal / Substância Cinzenta Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epilepsia do Lobo Temporal / Substância Cinzenta Idioma: En Ano de publicação: 2023 Tipo de documento: Article