Antifungal and antibiofilm activities of chromones against nine Candida species.
Microbiol Spectr
; 11(6): e0173723, 2023 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-37874140
ABSTRACT
IMPORTANCE The persistence of Candida infections is due to its ability to form biofilms that enable it to resist antifungals and host immune systems. Hence, inhibitions of the biofilm formation and virulence characteristics of Candida sp. provide potential means of addressing these infections. Among various chromone derivatives tested, four chromone-3-carbonitriles showed antifungal, antibiofilm, and antivirulence activities against several Candida species. Their mode of action has been partially revealed, and their toxicity is reported here using nematode and plant models.
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Base de dados:
MEDLINE
Assunto principal:
Candidíase
/
Antifúngicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article