Catalyst- and additive-free cascade radical addition/cyclization of N-arylacrylamides with trifluoropyruvates.
Chem Commun (Camb)
; 59(90): 13462-13465, 2023 Nov 09.
Article
em En
| MEDLINE
| ID: mdl-37877176
ABSTRACT
Herein, we introduce a photocatalyst- and additive-free method for the preparation of valuable 3,3-disubstituted oxindoles bearing trifluoromethyl alcohol moieties from readily available acrylamides and cheap trifluoropyruvates. The excited trifluoropyruvates under ultraviolet-light irradiation react efficiently with acrylamides delivering a variety of trifluoromethyl oxindoles with broad functional group tolerance and moderate to good yields. This protocol features mild reaction conditions, simple operation and ready scalability.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article