Increased circulating microRNA-21 level as a potential indicator for predicting a higher risk of incident fragility fractures.
J Osteopath Med
; 124(3): 121-125, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-37883102
ABSTRACT
CONTEXT As a common disease in the elderly, osteoporosis clearly increases the risk of fractures, leading to higher mortality, but the current markers to estimate the risk of fractures are limited. MicroRNA-21 (miR-21) may play an important role in osteoporosis, but the link of this biomarker with fractures was undetermined. OBJECTIVES:
We aimed to investigate the association between miR-21 levels and the presence of fragility fractures.METHODS:
A total of 200 patients were recruited and miR-21 was collected from baseline serum. The correlation between miR-21 and the fracture risk assessment tool (FRAX) score was analyzed. The incidence of fragility fractures was presented by Kaplan-Meier analysis, and Cox regression analysis was utilized to evaluate risk factors. The diagnostic value of miR-21 was conducted by the area under curve (AUC).RESULTS:
The FRAX score was significantly associated with miR-21 level (p<0.001). According to the 50th percentile of miR-21 content in the overall distribution, the cumulative incidence of fragility fractures was significantly higher in patients with higher miR-21 levels than those with lower levels (75.4, 95â¯% CI 69.0-81.8 vs. 59.2, 95â¯% CI 42.1-76.3, p<0.001). The results of the Cox regression analysis showed that the miR-21 level was an independent risk factor linked to the incidence of fracture (p=0.005). The optimal cut-off value of the miR-21 was 6.08, and the AUC for predicting fracture was 0.718 (95â¯% CI, 0.645-0.790).CONCLUSIONS:
This study showed that miR-21 has optimal diagnostic performance in the discrimination of fragility fracture, and the circulating miR-21 level in predicting the risk of fragility fracture may have a certain value.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Osteoporose
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MicroRNAs
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Fraturas por Osteoporose
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MicroRNA Circulante
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article