Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[<i>a</i>]quinolizidine Library to Induce Paraptosis for Cancer Therapy.

Sun, Yong; Zheng, Hongbo; Qian, Lilin; Liu, Yue; Zhu, Deyu; Xu, Zejun; Chang, Wenqiang; Xu, Jianwei; Wang, Lei; Sun, Bin; Gu, Lichuan; Yuan, Huiqing; Lou, Hongxiang

Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.

Sun, Yong; Zheng, Hongbo; Qian, Lilin; Liu, Yue; Zhu, Deyu; Xu, Zejun; Chang, Wenqiang; Xu, Jianwei; Wang, Lei; Sun, Bin; Gu, Lichuan; Yuan, Huiqing; Lou, Hongxiang.

Afiliação

Sun Y; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zheng H; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Qian L; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Liu Y; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zhu D; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xu Z; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Chang W; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Xu J; Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Wang L; Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Sun B; National Glycoengineering Research Center, Shandong University, Jinan 250100, China.
Gu L; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Yuan H; Key Laboratory of Experimental Teratology of the Ministry of Education, Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan 250013, China.
Lou H; Department of Natural Products Chemistry, Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.

JACS Au ; 3(10): 2749-2762, 2023 Oct 23.

Article em En | MEDLINE | ID: mdl-37885576

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article