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Nanoform of Phospholipid Composition: Investigation of the Morphological Features by Atomic Force Microscopy.
Kraevsky, Sergey V; Ivanova, Irina A; Kanashenko, Sergey L; Shumov, Ivan D; Ryazantsev, Ilya A; Tereshkina, Yulia A; Kostryukova, Lyubov V; Romashova, Yulia A; Pleshakova, Tatyana O.
Afiliação
  • Kraevsky SV; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Ivanova IA; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Kanashenko SL; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Shumov ID; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Ryazantsev IA; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Tereshkina YA; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Kostryukova LV; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Romashova YA; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
  • Pleshakova TO; Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow 119121, Russia.
Int J Mol Sci ; 24(20)2023 Oct 19.
Article em En | MEDLINE | ID: mdl-37895017
Morphological features of the nanoform of a phospholipid composition (NFPh), which can be used as an individual pharmaceutic agent or as a platform for designing drug delivery systems, have been studied using atomic force microscopy (AFM). NFPh has been developed, and its characteristics have been investigated using conventional drug analysis methods, including the determination of the mean diameter of nanosized vesicles in the emulsion via dynamic light scattering (DLS). Using DLS, the mean diameter of the vesicles was found to be ~20 nm. AFM imaging of the surface has revealed four types of objects related to NFPh: (1) compact objects; (2) layer fragments; (3) lamellar structures; and (4) combined objects containing the compact and extended parts. For type (4) objects, it has been found that the geometric ratio of the volume of the convex part to the total area of the entire object is constant. It has been proposed that these objects formed owing to fusion of vesicles of the same size (with the same surface-to-volume ratio). It has been shown that this is possible for vesicles with diameters of 20 nm. This diameter is in good coincidence with the value obtained using DLS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfolipídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfolipídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article