Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug-Drug Interactions of Phenytoin.

Rodriguez-Vera, Leyanis; Yin, Xuefen; Almoslem, Mohammed; Romahn, Karolin; Cicali, Brian; Lukacova, Viera; Cristofoletti, Rodrigo; Schmidt, Stephan.

Afiliação

Rodriguez-Vera L; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Yin X; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Almoslem M; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Romahn K; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Cicali B; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Lukacova V; Simulations Plus, Lancaster, CA 93534, USA.
Cristofoletti R; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Schmidt S; Center for Pharmacometrics and System Pharmacology at Lake Nona (Orlando), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.

Pharmaceutics ; 15(10)2023 Oct 18.

Article em En | MEDLINE | ID: mdl-37896246

Palavras-chave

cytochrome P450 2C19 (CYP2C19); cytochrome P450 2C9 (CYP2C9); drugdrug interactions (DDIs); phenytoin; physiologically based pharmacokinetic modelling (PBPK)

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article