Your browser doesn't support javascript.
loading
Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.
Ferar, Kathleen; Hall, Taryn O; Crawford, Dana C; Rowley, Robb; Satterfield, Benjamin A; Li, Rongling; Gragert, Loren; Karlson, Elizabeth W; de Andrade, Mariza; Kullo, Iftikhar J; McCarty, Catherine A; Kho, Abel; Hayes, M Geoffrey; Ritchie, Marylyn D; Crane, Paul K; Mirel, Daniel B; Carlson, Christopher; Connolly, John J; Hakonarson, Hakon; Crenshaw, Andrew T; Carrell, David; Luo, Yuan; Dikilitas, Ozan; Denny, Joshua C; Jarvik, Gail P; Crosslin, David R.
Afiliação
  • Ferar K; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA. kmuenzen@uw.edu.
  • Hall TO; Optum Genomics, UnitedHealth Group, Minnetonka, MN, USA.
  • Crawford DC; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
  • Rowley R; Department of Genetics and Genome Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
  • Satterfield BA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Li R; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
  • Gragert L; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Karlson EW; Division of Biomedical Informatics and Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
  • de Andrade M; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Kullo IJ; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
  • McCarty CA; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
  • Kho A; University of Minnesota Medical School, Duluth, MN, USA.
  • Hayes MG; Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.
  • Ritchie MD; Divisions of General Internal Medicine and Preventive Medicine, Northwestern University, Chicago, IL, USA.
  • Crane PK; Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Mirel DB; Department of Biochemistry and Molecular Biology, Center for Systems Genomics, Pennsylvania State University, University Park, PA, USA.
  • Carlson C; Division of General Internal Medicine, University of Washington, Seattle, WA, USA.
  • Connolly JJ; Scilligence Corp., Cambridge, MA, USA.
  • Hakonarson H; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Crenshaw AT; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Carrell D; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Luo Y; The Broad Institute of Harvard-MIT, Cambridge, MA, USA.
  • Dikilitas O; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
  • Denny JC; Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Jarvik GP; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
  • Crosslin DR; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Sci Rep ; 13(1): 18532, 2023 10 28.
Article em En | MEDLINE | ID: mdl-37898691
ABSTRACT
Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some patients with colons that are colonized with C. diff. do not develop any infection while others develop severe or recurrent infections. To identify common genetic variants associated with CDI, we performed a genome-wide association analysis in 19,861 participants (1349 cases; 18,512 controls) from the Electronic Medical Records and Genomics (eMERGE) Network. Using logistic regression, we found strong evidence for genetic variation in the DRB locus of the MHC (HLA) II region that predisposes individuals to CDI (P > 1.0 × 10-14; OR 1.56). Altered transcriptional regulation in the HLA region may play a role in conferring susceptibility to this opportunistic enteric pathogen.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Clostridium / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Clostridium / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2023 Tipo de documento: Article