Ni-Catalyzed Hydrosulfonylation of Alkenes with Aromatic Iodides and K2S2O5.
Org Lett
; 25(44): 8043-8047, 2023 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-37902301
ABSTRACT
Hydrosulfonylation of alkenes with readily available aromatic iodides via a SO2-insetion strategy is presented. The combination of non-noble Ni catalysis with (iPr)3SiH as the final reductant enables the efficient formation of aryl and heteroaryl sulfinate intermediates, which undergo Michael-type additions to electron-deficient alkenes for initiating the hydrosulfonylation process. Moreover, the superiority of this protocol is demonstrated by broad substrate scope and good functional group compatibility.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article