Association of lncRNA SOX2OT rs9839776 polymorphism with gastric cancer risk in Korean: Case-control study.
Medicine (Baltimore)
; 102(43): e35103, 2023 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-37904476
Aberrant regulation of the long non-coding RNA SRY-box transcription factor 2 overlapping transcript (SOX2OT) has been reported in various diseases including gastric cancer (GC). However, an association between the well-studied rs9839776 single nucleotide polymorphism in SOX2OT and GC susceptibility has not been reported. This study aimed to evaluate the association between the rs9839776 single nucleotide polymorphism in SOX2OT and GC risk. Genotyping of rs9839776 was conducted using TaqMan genotyping assay for 460 patients with GC and 386 controls. We found that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased GC risk (Pâ
=â
.046, adjusted odds ratio [AOR]â
=â
0.72, 95% confidence interval [CI]â
=â
0.52-1.00 and Pâ
=â
.044, AORâ
=â
0.74, 95% CIâ
=â
0.56-0.99, respectively). In addition, stratified analysis revealed that the dominant model (CT+TT) and rs9839776 T allele were significantly associated with decreased risk of lymph node metastasis-negative (Pâ
=â
.039, AORâ
=â
0.67, 95% CIâ
=â
0.46-0.98 and Pâ
=â
.049, AORâ
=â
0.71, 95% CIâ
=â
0.51-1.00, respectively) and tumor stage I (A+B)/II (A+B+C) (Pâ
=â
.028, AORâ
=â
0.66, 95% CIâ
=â
0.50-0.96 and Pâ
=â
.041, AORâ
=â
0.71, 95% CIâ
=â
0.52-0.99, respectively) GC. Our findings suggest that the rs9839776 T allele may be a protective factor against GC susceptibility. Further research is needed to clarify whether rs9839776 affects SOX2OT expression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
RNA Longo não Codificante
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article