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Sinonasal mucosal melanoma treatment response assessment to immune checkpoint inhibitors using hybrid positron emission tomography imaging.
Maurer, Alexander; Gstrein, Nathalie A; Dimitriou, Florentia; Sartoretti, Thomas; Schaab, Jan A; Looman, Esmée L; Balermpas, Panagiotis; Rupp, Niels J; Freiberger, Sandra N; Soyka, Michael B; Holzmann, David; Mauthe, Tina; Mueller, Simon A; Beintner-Skawran, Stephan; Messerli, Michael; Kenkel, David; Huellner, Martin W; Meerwein, Christian M.
Afiliação
  • Maurer A; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Gstrein NA; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
  • Dimitriou F; Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Sartoretti T; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Schaab JA; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Looman EL; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Balermpas P; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Rupp NJ; Department of Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Freiberger SN; Department of Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Soyka MB; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
  • Holzmann D; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
  • Mauthe T; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
  • Mueller SA; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
  • Beintner-Skawran S; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Messerli M; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Kenkel D; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Huellner MW; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Meerwein CM; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland. christian.meerwein@usz.ch.
Sci Rep ; 13(1): 18847, 2023 11 01.
Article em En | MEDLINE | ID: mdl-37914764
ABSTRACT
The purpose of this retrospective study was to investigate response of sinonasal mucosal melanoma (SMM) patients to treatment with immune checkpoint inhibitors (ICI), using hybrid PET imaging. Fifteen SMM patients underwent hybrid PET imaging before and three months after initiation of ICI. The disease-specific survival (DSS) was calculated. Quantitative PET parameters of the primary tumor and their association with DSS and therapy response were investigated. Nine of the fifteen (60%) patients responded to ICI therapy. Patients with therapy response depicted on hybrid PET imaging had better DSS than those without (p = 0.0058). Quantitative PET parameters of the initial PET harbored no association with DSS or therapy response. However, these findings lack of sufficient statistical power and must be interpreted with caution. The first restaging PET-imaging after ICI initiation can help stratify patients with regard to DSS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias dos Seios Paranasais / Melanoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias dos Seios Paranasais / Melanoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article