Dose-response association between cardiovascular health and mortality in cancer survivors.
Curr Probl Cardiol
; 49(1 Pt C): 102176, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37923028
ABSTRACT
BACKGROUND:
There is little knowledge on the dose-response association between cardiovascular health (CVH) and risk of all-cause, cardiovascular disease (CVD) and cancer deaths among cancer survivors.AIMS:
We aimed to examine the dose-response association of CVH with all-cause, CVD, and cancer mortality.METHODS:
A total of 1701 US adult cancer survivors were followed-up during a median of 7.3 (IQR 4.0-10.2) years from 2007 to 2018 through the National Health and Nutrition Examination Survey (NHANES). We used the American Heart Association´s (AHA) Life´s Essential 8 (LE8) as a proxy for CVH.RESULTS:
Restricted cubic spline models indicated a close to inverse linear shape for the dose-response association between LE8 score and all-cause mortality with significant risk reductions within the range between 61.25 (Hazard ratio [HR] 0.76, 95% CI, 0.59-0.98) and 100 points (HR 0.28, 95%CI, 0.12-0.62), and a curvilinear shape for the dose-response association between LE8 score and CVD deaths with significant risk reductions within the range between 50.25 (HR 0.72, 95% CI, 0.52-0.99) and 90.25 points (HR 0.15, 95%CI, 0.02-0.98). No significant dose-response association was observed between LE8 and cancer deaths.CONCLUSIONS:
Our study showed a close to inverse relationship between higher LE8 and risk of death from all cause, an inverse curvilinear relationship between higher LE8 and the risk for CVD death, and a non-significant association between higher LE8 and the risk of cancer death among US adult cancer survivors, which may translate to a substantial number of annual averted deaths and thus important public health implications.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Sobreviventes de Câncer
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Neoplasias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article