Role of affinity in plasma cell development in the germinal center light zone.
J Exp Med
; 221(1)2024 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-37938344
ABSTRACT
Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a stringent affinity-based barrier to PC development. Whether a similar high-affinity barrier regulates PC development under physiologic circumstances and the nature of the PC fate decision has not been defined precisely. Here, we use a fate-mapping approach to examine the relationship between GC B cells selected to undergo additional rounds of affinity maturation, GC pre-PC, and PC. The data show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time. Thus, whereas the GC continues to diversify over time, affinity-based pre-PC selection sieves the GC to enable the accumulation of a more restricted group of high-affinity antibody-secreting PC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plasmócitos
/
Centro Germinativo
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article