Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Nat Genet
; 55(12): 2065-2074, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37945903
ABSTRACT
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Predisposição Genética para Doença
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article