Chemical synthesis of the O-antigen repeating unit of Actinobacillus actinomycetemcomitans serotype f.
Carbohydr Res
; 534: 108977, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37949033
ABSTRACT
Herein, we report the total synthesis of the trisaccharide repeating unit of the O-antigen of Actinobacillus actinomycetemcomitans serotype f. The trisaccharide comprising of α-(1-2) and α-(1-3)-linked L-rhamnopyranosides backbone with the latter rhamnose containing a branching N-acetyl-d-galactosaminopyranoside at the C2-O via a ß-glycosidic bond was synthesized by two methods. Initially, the protected trisaccharide has been synthesized by step-wise assembly of the monosaccharide building blocks and subsequently the former was synthesized by the one-pot assembly of the latter components. The synthesized trisaccharide contains an aminoethyl linker appended as an O-glycoside at the reducing end, thereby providing scope for further conjugation for different applications.
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Base de dados:
MEDLINE
Assunto principal:
Aggregatibacter actinomycetemcomitans
/
Antígenos O
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article