InfluenCEF study: Clinical phenotype and duration of headache attributed to influenza infection.
Cephalalgia
; 43(11): 3331024231212900, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37950674
ABSTRACT
INTRODUCTION:
Headache is a frequent symptom of infections. We aimed to characterize the clinical phenotype and duration of headache attributed to influenza infection.METHODS:
Prospective cohort study done in 53 primary care centers between January and April 2023. Patients were included if they had a confirmed influenza diagnosis, were older than 15 years and had a new-onset headache. Patients' demographics, prior medical history, headache phenotype and duration, associated symptoms and patients' outcomes were assessed. The International Classification of Headache Disorders criteria for headache attributed to a systemic viral infection, migraine and tension-type headache were assessed.RESULTS:
Of the 478 patients 75 fulfilled eligibility criteria. The mean age was 43, 56% were men, and 27% had a prior headache history. The headache phenotype was a bilateral headache (52%), with frontal topography (48%), pressing quality (61%), moderate intensity, rhinorrhea (79%), nasal congestion (76%), and photophobia (59%). All patients fulfilled headache attributed to acute systemic viral infection criteria, 43% fulfilled migraine criteria and 31% tension-type headache criteria. The median duration of the headache was four (Inter-quartile range two-six) days.CONCLUSION:
The clinical phenotype of headache attributed to influenza infection was similar to other infections, with more pronounced cranial autonomic symptoms. The headache was an early symptom and was self-limited within a few days.Trial Registration The study protocol is registered in ClinicalTrial.gov (NCT05704335).Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cefaleia do Tipo Tensional
/
Influenza Humana
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Transtornos de Enxaqueca
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article