Mendelian Randomization Analyses Accounting for Causal Effect of COVID-19 on Brain Imaging-Derived Phenotypes.
J Alzheimers Dis
; 96(3): 1059-1070, 2023.
Article
em En
| MEDLINE
| ID: mdl-37955088
ABSTRACT
BACKGROUND:
The coronavirus disease 2019 (COVID-19) has been a major challenge to global health and a financial burden. Little is known regarding the possible causal effects of COVID-19 on the macro- and micro-structures of the human brain.OBJECTIVE:
To determine the causal links between susceptibility, hospitalization, and the severity of COVID-19 and brain imaging-derived phenotypes (IDPs).METHODS:
Mendelian randomization (MR) analyses were performed to investigate the causal effect of three COVID-19 exposures (SARS-CoV-2 infection, hospitalized COVID-19, and critical COVID-19) on brain structure employing summary datasets of genome-wide association studies.RESULTS:
In terms of cortical phenotypes, hospitalization due to COVID-19 was associated with a global decrease in the surface area (SA) of the cortex structure (ß=â-624.77, 95% CI -1227.88 to -21.66, pâ=â0.042). At the regional level, SARS-CoV-2 infection was found to have a nominally causal effect on the thickness (TH) of the postcentral region (ß=â-0.004, 95% CI -0.007 to -0.001, pâ=â0.01), as well as eight other IDPs. Hospitalized COVID-19 has a nominally causal relationship with TH of postcentral (ß=â-0.004, 95% CI -0.007 to -0.001, pâ=â0.01) and other 6 IDPs. The nominally causal effects of critical COVID-19 on TH of medial orbitofrontal (ß=0.004, 95% CI 0.001to 0.007, pâ=â0.004) and other 7 IDPs were revealed.CONCLUSIONS:
Our study provides compelling genetic evidence supporting causal relationships between three COVID-19 traits and brain IDPs. This discovery holds promise for enhancing predictions and interventions in brain imaging.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Estudo de Associação Genômica Ampla
/
COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article