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Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies.
Tang, Mi; Xiong, Liling; Cai, Jianghui; Fu, Jinzhu; Liu, Hong; Ye, Ying; Yang, Li; Xing, ShaSha; Yang, Xiao.
Afiliação
  • Tang M; GCP Institution, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Xiong L; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Cai J; Obstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Fu J; Department of Pharmacy, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Liu H; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Ye Y; Obstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Yang L; Operating Theater, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Xing S; Operating Theater, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Yang X; Obstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Hepatol Int ; 18(1): 50-62, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37957532
Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease. It is characterized by pruritus, abnormal liver function and elevated total bile acid (TBA) levels, increasing the risk of maternal and fetal adverse outcomes. Its etiology remains poorly elucidated. Over the years, various omics techniques, including metabolomics, microbiome, genomics, etc., have emerged with the advancement of bioinformatics, providing a new direction for exploring the pathogenesis, diagnosis and treatment of ICP. In this review, we first summarize the role of bile acids and related components in the pathogenesis of ICP and then further illustrate the results of omics studies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Colestase Intra-Hepática Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Colestase Intra-Hepática Idioma: En Ano de publicação: 2024 Tipo de documento: Article