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Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment.
Almousa, Rashed; Xie, Dong; Chen, Yong; Li, Jiliang; Anderson, Gregory G.
Afiliação
  • Almousa R; Weldon School of Biomedical Engineering, Purdue University, West Lafayette IN, USA.
  • Xie D; Department of Medical Equipment Technology, Majmaah University, Al-Majmaah, Saudi Arabia.
  • Chen Y; Weldon School of Biomedical Engineering, Purdue University, West Lafayette IN, USA.
  • Li J; Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States.
  • Anderson GG; Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States.
J Biomater Appl ; 38(6): 758-771, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37963494
The objective of this study was to coat negatively charged polymer brushes covalently onto the surface of thermoplastic polyurethane (TPU) using a simple conventional surface free-radical polymerization technique. The coated surfaces were assessed with contact angle, protein adsorption, cell adhesion and bacterial adhesion. Bovine serum albumin (BSA) and bovine fibrinogen (BFG) were used for protein adsorption evaluation. Mouse fibroblasts (NIH-3T3) and Pseudomonas aeruginosa (P. aeruginosa) were used to assess surface adhesion. Results show that the TPU surface modified with the attached polymer brushes exhibited significantly reduced contact angle, protein adsorption, and cell as well as bacterial adhesion, among which the negatively charged polymers showed the extremely low values in all the tests. Its contact angle is 5°, as compared to 70° for original TPU. Its BSA, BFG, 3T3 adhesion and P. aeruginosa adhesion were 93%, 84%, 92%, and 93% lower than original TPU. Furthermore, the TPU surface coated with negatively charged polymer brushes exhibited a hydrogel-like property. The results indicate that placing acrylic acids using a simple surface-initiated free-radical polymerization onto a TPU surface and then converting those to negative charges can be an effective and efficient route for fouling resistant applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Poliuretanos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Poliuretanos Idioma: En Ano de publicação: 2024 Tipo de documento: Article