Decarboxylative halogenation of indoles by vanadium haloperoxidases.
Chem Commun (Camb)
; 59(96): 14289-14292, 2023 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-37964599
ABSTRACT
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article