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Decarboxylative halogenation of indoles by vanadium haloperoxidases.
Harstad, Lauren J; Wells, Clare E; Lee, Hyung Ji; Ramos, Lauren P T; Sharma, Manik; Pascoe, Cameron A; Biegasiewicz, Kyle F.
Afiliação
  • Harstad LJ; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Wells CE; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Lee HJ; Department of Chemistry, Emory University, Atlanta, GA 30322, USA. kbiegas@emory.edu.
  • Ramos LPT; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Sharma M; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
  • Pascoe CA; Department of Chemistry, Emory University, Atlanta, GA 30322, USA. kbiegas@emory.edu.
  • Biegasiewicz KF; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
Chem Commun (Camb) ; 59(96): 14289-14292, 2023 Nov 30.
Article em En | MEDLINE | ID: mdl-37964599
ABSTRACT
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article