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Methodology for Good Machine Learning with Multi-Omics Data.
Coroller, Thibaud; Sahiner, Berkman; Amatya, Anup; Gossmann, Alexej; Karagiannis, Konstantinos; Moloney, Conor; Samala, Ravi K; Santana-Quintero, Luis; Solovieff, Nadia; Wang, Craig; Amiri-Kordestani, Laleh; Cao, Qian; Cha, Kenny H; Charlab, Rosane; Cross, Frank H; Hu, Tingting; Huang, Ruihao; Kraft, Jeffrey; Krusche, Peter; Li, Yutong; Li, Zheng; Mazo, Ilya; Paul, Rahul; Schnakenberg, Susan; Serra, Paolo; Smith, Sean; Song, Chi; Su, Fei; Tiwari, Mohit; Vechery, Colin; Xiong, Xin; Zarate, Juan Pablo; Zhu, Hao; Chakravartty, Arunava; Liu, Qi; Ohlssen, David; Petrick, Nicholas; Schneider, Julie A; Walderhaug, Mark; Zuber, Emmanuel.
Afiliação
  • Coroller T; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Sahiner B; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Amatya A; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Gossmann A; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Karagiannis K; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Moloney C; Novartis Pharma AG, Rotkreuz, Switzerland.
  • Samala RK; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Santana-Quintero L; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Solovieff N; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Wang C; Novartis Pharma AG, Rotkreuz, Switzerland.
  • Amiri-Kordestani L; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Cao Q; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Cha KH; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Charlab R; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Cross FH; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Hu T; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Huang R; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Kraft J; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Krusche P; Novartis Pharma AG, Rotkreuz, Switzerland.
  • Li Y; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Li Z; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Mazo I; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Paul R; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Schnakenberg S; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Serra P; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Smith S; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Song C; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Su F; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Tiwari M; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Vechery C; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Xiong X; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Zarate JP; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Zhu H; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Chakravartty A; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Liu Q; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Ohlssen D; Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
  • Petrick N; Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Schneider JA; Oncology Center of Excellence, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Walderhaug M; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
  • Zuber E; Novartis Pharma AG, Rotkreuz, Switzerland.
Clin Pharmacol Ther ; 115(4): 745-757, 2024 04.
Article em En | MEDLINE | ID: mdl-37965805
ABSTRACT
In 2020, Novartis Pharmaceuticals Corporation and the U.S. Food and Drug Administration (FDA) started a 4-year scientific collaboration to approach complex new data modalities and advanced analytics. The scientific question was to find novel radio-genomics-based prognostic and predictive factors for HR+/HER- metastatic breast cancer under a Research Collaboration Agreement. This collaboration has been providing valuable insights to help successfully implement future scientific projects, particularly using artificial intelligence and machine learning. This tutorial aims to provide tangible guidelines for a multi-omics project that includes multidisciplinary expert teams, spanning across different institutions. We cover key ideas, such as "maintaining effective communication" and "following good data science practices," followed by the four steps of exploratory projects, namely (1) plan, (2) design, (3) develop, and (4) disseminate. We break each step into smaller concepts with strategies for implementation and provide illustrations from our collaboration to further give the readers actionable guidance.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inteligência Artificial / Multiômica Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inteligência Artificial / Multiômica Idioma: En Ano de publicação: 2024 Tipo de documento: Article