Long-term outcome of bicuspid aortic valve disease.
Eur Heart J Cardiovasc Imaging
; 25(3): 425-435, 2024 Feb 22.
Article
em En
| MEDLINE
| ID: mdl-37966276
ABSTRACT
AIMS:
Bicuspid aortic valve (BAV) is a common congenital condition that is frequently associated with aortic stenosis (AS) and aortic regurgitation (AR), as well as aortic aneurysms, but specific outcome data are scarce. The present study sought to assess outcomes in a large cohort of consecutive patients with BAV. METHODS ANDRESULTS:
A total of 581 consecutive patients (median age 29 years, 157 female) with BAV were included in the study and followed prospectively in a heart valve clinic follow-up programme. The overall survival rate after 10 years was 94.5%. During follow-up, 158 patients developed an indication for surgery. Event-free survival rates were 97%, 94%, 87%, and 73% at 1, 2, 5, and 10 years, respectively. In the multivariable analysis, event rates were independently predicted by AS [subdistribution hazard ratio (SHR) 2.3 per degree of severity], AR (SHR 1.5 per degree of severity), baseline aortic dilatation ≥ 40â mm (SHR 1.9), and age (SHR 1.3) (P < 0.001).CONCLUSION:
BAV disease is associated with a high rate of cardiac events, but state-of-the-art care results in good survival with low rates of infective endocarditis, aortic dissection, and sudden death. Incremental degrees of AS and regurgitation, the presence of aortic dilatation, and age are predictive of cardiac events.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Insuficiência da Valva Aórtica
/
Estenose da Valva Aórtica
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Doença da Válvula Aórtica Bicúspide
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Doenças das Valvas Cardíacas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article