Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.

Li, Shuangyu; Ma, Qiubo; Ma, Zengwei; Shi, Ying; Yu, Xiaoyan; Gu, Baohua; Sun, Shanshan; Yu, Chunlei; Pang, Lei

Li, Shuangyu; Ma, Qiubo; Ma, Zengwei; Shi, Ying; Yu, Xiaoyan; Gu, Baohua; Sun, Shanshan; Yu, Chunlei; Pang, Lei.

Afiliação

Li S; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Ma Q; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Ma Z; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Shi Y; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yu X; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Gu B; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Sun S; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yu C; Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Pang L; Department of Nephrology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.

Clin Hemorheol Microcirc ; 86(3): 369-382, 2024.

Article em En | MEDLINE | ID: mdl-37980653

Assuntos

MicroRNAs; Traumatismo por Reperfusão; Ratos; Animais; NF-kappa B/metabolismo; Interleucina-10/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Canal de Cátion TRPC6/genética; Canal de Cátion TRPC6/metabolismo; Creatinina/farmacologia; Transdução de Sinais; Ratos Sprague-Dawley; Rim/patologia; Citocinas/metabolismo; Traumatismo por Reperfusão/genética; Traumatismo por Reperfusão/patologia; MicroRNAs/genética; MicroRNAs/metabolismo; Luciferases/metabolismo; Luciferases/farmacologia

Palavras-chave

NF-κB p65; TRPC6; gene targeting; ischemia-reperfusion; kidney; miR-150

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / MicroRNAs Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / MicroRNAs Idioma: En Ano de publicação: 2024 Tipo de documento: Article