Proactive Infliximab Monitoring Improves the Rates of Transmural Remission in Crohn's Disease: A Propensity Score-Matched Analysis.
Inflamm Bowel Dis
; 2023 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-37982426
ABSTRACT
BACKGROUND:
Few patients can reach transmural remission in Crohn's disease (CD) with currently available therapies. Proactive optimization of infliximab (IFX) based on trough levels may potentially improve these results.METHODS:
Retrospective cohort study including consecutive CD patients starting treatment with IFX. Rates of transmural remission were compared between patients with and without therapeutic drug monitoring (target level 5-7 µg/mL). A propensity score-matched analysis was performed to adjust for potential confounders.RESULTS:
A total of 195 CD patients were included, 57.9% receiving proactive therapeutic drug monitoring. The rates of transmural remission were higher in patients under proactive therapeutic drug monitoring (37.2% vs 18.3%; Pâ =â .004) with similar results in the propensity score-matched analysis (34.2% vs 17.1%; Pâ =â .025). In multivariate analysis, proactive therapeutic drug monitoring was independently associated with transmural remission (odds ratio, 2.95; 95% confidence interval, 1.44-6.06; Pâ =â .003).CONCLUSIONS:
Proactive optimization of IFX based on trough levels increases the rates of transmural remission in CD.
In the following study, we demonstrate that proactive optimization of infliximab using a trough level protocol (aim 5-7 µg/mL) results in higher rates of transmural remission compared with conventional infliximab treatment. These results remained significant in a propensity scorematched analysis.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article