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Stereocontrolled synthesis of new iminosugar lipophilic derivatives and evaluation of biological activities.
De Angelis, Martina; Primitivo, Ludovica; Sappino, Carla; Centrella, Barbara; Lucarini, Claudia; Lanciotti, Lucrezia; Petti, Alessia; Odore, Davide; D'Annibale, Andrea; Macchi, Beatrice; Stefanizzi, Valeria; Cirigliano, Angela; Rinaldi, Teresa; Righi, Giuliana; Ricelli, Alessandra.
Afiliação
  • De Angelis M; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy. Electronic address: m.deangelis@uniroma1.it.
  • Primitivo L; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Sappino C; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Centrella B; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Lucarini C; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Lanciotti L; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Petti A; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Odore D; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • D'Annibale A; Department of Chemistry, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Macchi B; Department of Chemical Science and Technology, University of Rome "Tor Vergata", Via Cracovia, 50, 00133, Rome, Italy.
  • Stefanizzi V; Department of Chemical Science and Technology, University of Rome "Tor Vergata", Via Cracovia, 50, 00133, Rome, Italy.
  • Cirigliano A; Institute of Molecular Biology and Pathology (IBPM)-CNR, P.le A. Moro 5, 00185, Rome, Italy.
  • Rinaldi T; Department of Biology and Biotechnology, "Sapienza" University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Righi G; Institute of Molecular Biology and Pathology (IBPM)-CNR, P.le A. Moro 5, 00185, Rome, Italy.
  • Ricelli A; Institute of Molecular Biology and Pathology (IBPM)-CNR, P.le A. Moro 5, 00185, Rome, Italy.
Carbohydr Res ; 534: 108984, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37984279
ABSTRACT
Iminosugars' similarity to carbohydrates determines the exceptional potential for this class of polyhydroxylated alkaloids to serve as potential drug candidates for a wide variety of diseases such as diabetes, lysosomal storage diseases, cancer, bacterial and viral infections. The presence of lipophilic substituents has a significant impact on their biological activities. This work reports the synthesis of three new pyrrolidine lipophilic derivatives O-alkylated in C-6 position. The biological activities of our iminosugars' collection were tested in two cancer cell lines and, due to the pharmaceutical potential, in the model yeast system Saccharomyces cerevisiae to assess their toxicity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imino Açúcares Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imino Açúcares Idioma: En Ano de publicação: 2023 Tipo de documento: Article