Stereocontrolled synthesis of new iminosugar lipophilic derivatives and evaluation of biological activities.
Carbohydr Res
; 534: 108984, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37984279
ABSTRACT
Iminosugars' similarity to carbohydrates determines the exceptional potential for this class of polyhydroxylated alkaloids to serve as potential drug candidates for a wide variety of diseases such as diabetes, lysosomal storage diseases, cancer, bacterial and viral infections. The presence of lipophilic substituents has a significant impact on their biological activities. This work reports the synthesis of three new pyrrolidine lipophilic derivatives O-alkylated in C-6 position. The biological activities of our iminosugars' collection were tested in two cancer cell lines and, due to the pharmaceutical potential, in the model yeast system Saccharomyces cerevisiae to assess their toxicity.
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MEDLINE
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Imino Açúcares
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article