Loss of ESRP2 Activates TAK1-MAPK Signaling through the Fetal RNA-Splicing Program to Promote Hepatocellular Carcinoma Progression.

Yan, Qian; Fang, Xiaona; Liu, Xiaoxia; Guo, Sai; Chen, Siqi; Luo, Min; Lan, Ping; Guan, Xin-Yuan

Yan, Qian; Fang, Xiaona; Liu, Xiaoxia; Guo, Sai; Chen, Siqi; Luo, Min; Lan, Ping; Guan, Xin-Yuan.

Afiliação

Yan Q; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Fang X; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Liu X; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Guo S; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.
Chen S; Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Luo M; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Lan P; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Guan XY; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.

Adv Sci (Weinh) ; 11(1): e2305653, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37985644

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Camundongos; Animais; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Hepatócitos/metabolismo; Processamento Alternativo/genética; Isoformas de Proteínas/genética; RNA/metabolismo; Proteínas de Ligação a RNA/metabolismo

Palavras-chave

RNA splicing; TAK1/MAPK activation; epithelial splicing regulatory protein 2; fetal reprogramming; hepatocellular carcinoma

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Idioma: En Ano de publicação: 2024 Tipo de documento: Article