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Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects.
Mably, John D; Wang, Da-Zhi.
Afiliação
  • Mably JD; Center for Regenerative Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Wang DZ; USF Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Nat Rev Cardiol ; 21(5): 326-345, 2024 May.
Article em En | MEDLINE | ID: mdl-37985696
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their possible biological roles and effects on development and disease. ncRNAs have been touted as previously uncharacterized regulators of gene expression and cellular processes, possibly working to fine-tune these functions. The sheer number of ncRNAs identified has outpaced the capacity to characterize each molecule thoroughly and to reliably establish its clinical relevance; it has, nonetheless, created excitement about their potential as molecular targets for novel therapeutic approaches to treat human disease. In this Review, we focus on one category of ncRNAs - long non-coding RNAs - and their expression, functions and molecular mechanisms in cardiac hypertrophy and heart failure. We further discuss the prospects for this specific class of ncRNAs as novel targets for the diagnosis and treatment of these conditions.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article