Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment.

DeVries, Sarah A; Conner, Bryce; Dimovasili, Christina; Moore, Tara L; Medalla, Maria; Mortazavi, Farzad; Rosene, Douglas L

DeVries, Sarah A; Conner, Bryce; Dimovasili, Christina; Moore, Tara L; Medalla, Maria; Mortazavi, Farzad; Rosene, Douglas L.

Afiliação

DeVries SA; Laboratory for Cognitive Neurobiology, Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Campus, Boston, MA, USA. sdevries@bu.edu.
Conner B; Laboratory for Cognitive Neurobiology, Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Campus, Boston, MA, USA.
Dimovasili C; Laboratory for Cognitive Neurobiology, Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Campus, Boston, MA, USA.
Moore TL; Laboratory for Cognitive Neurobiology, Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Campus, Boston, MA, USA.
Medalla M; Center for Systems Neuroscience, Boston University, Boston, MA, USA.
Mortazavi F; Laboratory for Cognitive Neurobiology, Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Campus, Boston, MA, USA.
Rosene DL; Center for Systems Neuroscience, Boston University, Boston, MA, USA.

Geroscience ; 46(2): 2503-2519, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37989825

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Humanos; Idoso; Microglia; Complemento C1q/genética; Complemento C1q/metabolismo; Antígeno CD47/metabolismo; Encéfalo/metabolismo; Disfunção Cognitiva/metabolismo; Doença de Alzheimer/metabolismo; Sinapses/metabolismo

Palavras-chave

Aging; C1q; CD47; Cognitive decline; Microglia; Synapse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Idioma: En Ano de publicação: 2024 Tipo de documento: Article