Moslosooflavone protects against brain injury induced by hypobaric hypoxic via suppressing oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis.
J Pharm Pharmacol
; 76(1): 44-56, 2024 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-37991718
ABSTRACT
OBJECTIVES:
To investigate the protect effect of moslosooflavone against brain injury induced by hypobaric hypoxia (HH) in mice.METHODS:
Protective effects of moslosooflavone in oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis were studied in HH-induced brain damage mice. The pathological morphology in the cortex of mice was determined by hematoxylin and eosin staining. The related protein expressions were detected by western blot. KEYFINDINGS:
Moslosooflavone improved HH-induced brain histopathological changes, reduced the contents of ROS and MDA, and elevated the levels of antioxidant enzymes and GSH in HH-exposed brains of mice. Moslosooflavone also markedly enhanced the ATPase activities and PK, ATP contents, while reducing LDH activity and the LD, TNF-α, IL-1ß, and IL-6 contents HH-exposed brains of mice. In addition, moslosooflavone notably decreased the expression of HIF-1α, VEGF, Bax, and cleaved caspase-3 dramatically increasing the expression of Bcl-2, Nrf2, and HO1 in HH-exposed brains of mice.CONCLUSIONS:
Our current studies indicate that moslosooflavone protects HH-induced brain injury possibly through alleviating oxidative stress and neuroinflammation, maintaining the balance of energy metabolism, and inhibiting cell apoptosis.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Doenças Neuroinflamatórias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article