Analgesic Buxus alkaloids with Enhanced Selectivity for the Low-Voltage-Gated Calcium Channel Ca<sub>v</sub> 3.2 over Ca<sub>v</sub> 3.1 through a New Binding Mode.

Gong, Ye; Liu, Rui; Zha, Hongjing; Dong, Ding; Lu, Nihong; Yan, Hui; Wan, Luosheng; Nian, Yin

Analgesic Buxus alkaloids with Enhanced Selectivity for the Low-Voltage-Gated Calcium Channel Ca_v 3.2 over Ca_v 3.1 through a New Binding Mode.

Gong, Ye; Liu, Rui; Zha, Hongjing; Dong, Ding; Lu, Nihong; Yan, Hui; Wan, Luosheng; Nian, Yin.

Afiliação

Gong Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China.
Liu R; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China.
Zha H; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, P. R. China.
Dong D; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China.
Lu N; Department of Respiratory Medicine, The Third People's Hospital of Kunming, Kunming, 650041, Yunnan, P. R. China.
Yan H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China.
Wan L; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, P. R. China.
Nian Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China.

Angew Chem Int Ed Engl ; 63(1): e202313461, 2024 Jan 02.

Article em En | MEDLINE | ID: mdl-37997012

Assuntos

Alcaloides; Buxus; Camundongos; Animais; Canais de Cálcio; Analgésicos/farmacologia; Dor; Alcaloides/farmacologia; Camundongos Knockout; Cálcio

Palavras-chave

Analgesic Agents; Buxus Alkaloids; Cav3.2; Ion Channels; Natural Products

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Buxus / Alcaloides Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Buxus / Alcaloides Idioma: En Ano de publicação: 2024 Tipo de documento: Article