Association between Dental Scores and Saliva Uremic Toxins.
Toxins (Basel)
; 15(11)2023 11 20.
Article
em En
| MEDLINE
| ID: mdl-37999529
ABSTRACT
Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.
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Base de dados:
MEDLINE
Assunto principal:
Toxinas Biológicas
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Uremia
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Insuficiência Renal Crônica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article