Allergy: Evaluation of 16 years (2007-2022) results of the shared external quality assessment program in Belgium, Finland, Portugal and The Netherlands.
Clin Chem Lab Med
; 2023 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-38008748
OBJECTIVES: This paper evaluates 16 year results of the Allergy EQA program shared by EQA organisers in Belgium, Finland, Portugal, and The Netherlands. METHODS: The performance of Thermo Fisher and Siemens user groups (in terms of concordance between both groups, between laboratory CV, prevalence of clinically significant errors) and suitability of samples (stability and validity of dilution of patient samples) are evaluated using data of 192 samples in the EQA programs from 2007 to 2022. Measurands covered are total IgE, screens and mixes, specific IgE extracts and allergen components. RESULTS: There is perfect (53â¯%), acceptable (40â¯%) and poor (6â¯%) concordance between both method groups. In case of poor concordance the best fit with clinical data is seen for Thermo Fisher (56â¯%) and Siemens (26â¯%) respectively. The between laboratory CV evolves from 7.8 to 6.6â¯% (Thermo Fisher) and 7.3 to 7.7â¯% (Siemens). The prevalence of blunders by individual laboratories is stable for Siemens (0.4â¯%) and drops from 0.4 to 0.2â¯% for Thermo Fisher users. For IgE, the between year CV of the mean of both user groups is 1â¯%, and a fifteen-fold dilution of a patient sample has an impact of 2 and 4â¯% on the recovery of Thermo Fisher and Siemens user groups. CONCLUSIONS: The analytical performance of Thermo Fisher is slightly better than that of Siemens users but the clinical impact of this difference is limited. Stability of the sample and the low impact of dilution on the recovery of measurands demonstrates the suitability for purpose of the EQA program.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article